Analysis Techniques

In order to better provide customers with analytical services, BOC Sciences is equipped with a series of top-notch instruments and equipment. We have hired professional equipment managers, and regularly organize business training to update our technical list. In order to ensure the accuracy of the analysis results, we will also get in touch with the equipment suppliers to maintain and calibrate all the instruments. More importantly, our analysis service can be provided to you as a separate service item.

Our analysis services run through the whole process of the project, and all data will be recorded in the book. The analytical methods used have also passed verification. Finally, it will be submitted to you and the quality supervision department together with the operator verification and QP statement.

Our Drug Testing Equipment

BOC Sciences offers a comprehensive range of pharmaceutical analysis technologies and instrumentation designed to meet the diverse needs of the pharmaceutical industry. We place a strong emphasis on accuracy, sensitivity and efficiency, and our advanced analytical techniques and instrumentation are critical to ensuring the safety and effectiveness of our medicines. Whether identifying impurities, determining active ingredients, or evaluating physical and chemical properties, BOC Sciences has the expertise and technology to provide reliable, accurate results for pharmaceutical analysis. Our list of equipment used for pharmaceutical analysis includes:

Mass spectrometry: organic mass spectrometer, inorganic massspectrometer, isotope mass spectrometer, ion probe, etc.

Mainly used for impurity evaluation in drug development, purity evaluation of active pharmaceutical ingredients, amino acid sequence analysis and other applications.

Spectroscopy: UV-Vis, AAS, AFS, Raman Microscope, FTIR Spectrometer, CD, polarimetric analyzer, etc.

Mainly used for the analysis of physical and chemical parameters of APls and excipients, such as crystal form, particle size and moisture. It can also be used to determine active pharmaceutical ingredients and provide a reference for the quality control of bulk drugs and drug production.

Chromatography: gas chromatograph, liquid chromatograph, ion chromatograph, thin-layer scanning chromatograph, gel chromatograph, supercritical chromatograph, electrophoresis, etc.

Mainly used for structural analog analysis, analysis of large and small polar compounds, analysis of lipid compounds, preparation of volatile samples, separation and purification of components, etc.

Thermal analysis instruments: differential thermal analyzer, differential scanning calorimeter, thermal balance, thermal conductivity tester, thermal expansion coefficient tester, etc.

Thermal analysis methods are widely used in chemical drug inspection, reference substance development and quality control, and play an important role in melting point, crystal form, purity determination and so on.

Mechanical testing equipment: material testing machine, hardness tester, high temperature and high pressure triaxial tester, surface interfacial tension tester, contact angle measuring device, viscometer, etc.

They can provide information on physical properties such as solid form, viscosity and elasticity, particle size, mechanical properties (for example, tensile or compressive force), stability, and pharmaceutical appearance.

In addition to the above equipment, to bring you a more comprehensive service experience, we can also provide the following equipment:

Our Pharmaceutical Analysis Techniques

Drug analysis is the use of chemistry, physics, biology and microbiology techniques to study the chemical testing, stability, bioavailability, clinical monitoring of drugs and the qualitative and quantitative determination of active ingredients in Chinese herbal medicines. It includes chemical testing of finished drugs, quality control of the drug production process, quality inspection of the drug storage process, clinical drug analysis, in vivo drug analysis, etc. The main methods of drug analysis include chemical, physical and biological analysis methods. Chemical testing refers to the chemical properties, reaction intensity and impact of drugs under a series of chemical reaction conditions such as chemical analysis instruments. It is the most widely used and important method in today's drug quality inspection and testing, and can comprehensively analyze and evaluate the quality and effect of drugs. Physical testing methods refer to testing the physical and mechanical properties of drugs under the action of conventional physical conditions such as electricity, heat, and light. Biotechnology methods mainly include electrophoresis technology and PCR technology.

BOC Sciences provides a comprehensive range of pharmaceutical analysis methods, including gravimetric methods, acid-base titration methods, pH value determination methods, spectroscopic techniques, chemiluminescence techniques, chromatography, electrophoresis, DNA amplification methods, etc. These analytical techniques are critical for the characterization and quality control of pharmaceutical products, ensuring drug safety and effectiveness. With state-of-the-art instrumentation and a team of experienced scientists, BOC Sciences is committed to providing accurate and reliable drug analysis services to support the pharmaceutical industry and advance the development of new therapeutics.

Gravimetric Analysis

Gravimetry is a basic technique in pharmaceutical analysis that involves measuring the mass of a substance to determine its purity or concentration. This method is based on the principle that the mass of a pure substance is directly proportional to its chemical composition. Gravimetric analysis is commonly used to determine the purity of drug substances and the content of active pharmaceutical ingredients (APIs) in pharmaceutical products. BOC Sciences utilizes state-of-the-art analytical balances and precision weighing technology to ensure accurate and reliable results.

Acid-Base Titration Analysis

Acid-base titration is another important tool in pharmaceutical analysis, especially for determining the concentration of acids and bases in pharmaceutical preparations. The method involves the gradual addition of a known concentration of titrant to the analyte until the equivalence point is reached, at which point the reaction is stoichiometrically complete. BOC Sciences can perform acid-base titrations with high precision and accuracy using automated titration systems and high-quality reagents.

pH Value Determination

pH measurements are critical for assessing the acidity or alkalinity of pharmaceutical formulations and monitoring the stability of drug substances. BOC Sciences utilizes pH meters and electrodes to measure the pH of drug solutions and formulations, ensuring the pH is within the specified range for optimal stability and efficacy.

Spectroscopic Techniques

Spectroscopic techniques, including UV-visible spectroscopy, infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy, are powerful tools in pharmaceutical analysis for identifying and quantifying drugs. BOC Sciences has extensive experience in applying spectroscopic techniques for pharmaceutical analysis, using advanced spectrophotometers and spectrometers to obtain accurate and reliable results. Our UV-Vis spectroscopy is often used for quantitative analysis of drugs because it is sensitive to the presence of chromophores in drug molecules. Infrared spectroscopy can be used to identify functional groups in drugs, while NMR spectroscopy can provide detailed structural information about drug molecules.

Chemiluminescence Techniques

Chemiluminescence technology is used in pharmaceutical analysis to detect specific compounds based on their ability to emit light as a result of chemical reactions. This method is particularly useful for the determination of trace impurities or contaminants in pharmaceutical products. BOC Sciences also supports the use of chemiluminescence analyzers to detect and quantify low-level impurities in drug substances and dosage forms to ensure drug safety and quality.

Chromatographic Analysis

Chromatography is a versatile and widely used technique in pharmaceutical analysis and includes methods such as high-performance liquid chromatography (HPLC), gas chromatography (GC), and thin-layer chromatography (TLC). HPLC is the most commonly used chromatographic method in pharmaceutical analysis, providing high resolution and sensitivity for the separation and quantification of drug substances and impurities. GC is suitable for the analysis of volatile compounds, while TLC is a simple and cost-effective method for qualitative analysis of pharmaceuticals. BOC Sciences has extensive expertise in the application of chromatography techniques for pharmaceutical analysis, and we typically utilize state-of-the-art chromatography systems and columns to achieve accurate and precise separations of various forms of pharmaceuticals.

Electrophoretic Analysis

Electrophoresis is a powerful technique used to separate and analyze charged molecules such as proteins, nucleic acids, and carbohydrates. This method is widely used in the characterization of biopharmaceuticals and the analysis of drug impurities. BOC Sciences can analyze pharmaceutical products using capillary electrophoresis and gel electrophoresis, providing detailed information on the composition and purity of the drug substance.

DNA Amplification Techniques

DNA amplification methods, such as polymerase chain reaction (PCR), are critical for the detection and quantification of nucleic acid sequences in pharmaceutical products. This method is particularly important for the analysis of biopharmaceuticals, including gene therapies and recombinant proteins. BOC Sciences is committed to ensuring the safety and quality of biopharmaceutical products by utilizing PCR and other DNA amplification technologies to detect and quantify nucleic acid impurities with high sensitivity and specificity.

In addition to advanced analytical instrumentation and technology, BOC Sciences offers a comprehensive range of pharmaceutical analytical services, including method development and validation, stability studies, microbiological testing, impurity studies, and more. Please refer to Analysis Services for more relevant details. If you are interested in our analysis techniques, please contact us immediately. We are always ready to provide you with reliable services.