Steroids & Hormones Custom Development

Hormones such as steroids have important applications in the pharmaceutical industry. In recent years, the market size has become larger and larger, and many new steroid-based drugs have been produced. BOC Sciences can use a combination of microbiology and chemical processes to design synthetic steroid active pharmaceutical ingredients. We can reduce your research and development costs and provide customized development services with our unique know-how. In order to develop complex steroids and other hormone drugs, we have established a special R&D base in the United States. There are more than 50 scientists working enthusiastically in the base. We also have a professional production factory that can provide first-class manufacturing services.

What is Steroid Hormone?

Hormones are molecules produced and secreted by endocrine glands in the body. Hormones are released into the bloodstream and travel to other parts of the body where they bring about specific reactions in particular cells. Steroid hormones are derived from cholesterol and are fat-soluble molecules. Examples of steroid hormones include the sex hormones produced by the male and female gonads (androgens, estrogens, and progesterone) and the adrenal hormones (aldosterone, cortisol, and androgens). Steroid hormones act on cells by traveling through cell membranes, entering the nucleus, binding to DNA and initiating gene transcription and protein production.

Fig. 1. Mechanism of action of steroid hormones (Nuclear Receptor Signaling. 2007, 5: e005).

What are Steroid Hormone Drugs?

Steroid hormone drugs are hormone drugs that contain a steroidal structure in their molecular structure. They are an important class of drugs used in clinical practice, and include two main classes: adrenocorticotropic hormones and sex hormones. Corticosteroid drugs used in clinical practice include cortisone acetate, hydrocortisone, oexamethasone acetate, fluocinonide, and so on. Sex hormones are divided into androgens and anabolic hormones, estrogens and progestins, such as methytestosterone, norandrostenolone, ethinylestradiol, progesterone and other drugs.

Application of Steroid Hormone Drugs

Immune system diseases: rheumatoid arthritis, systemic lupus erythematosus, scleroderma, etc.
Respiratory system diseases: treatment of asthma, chronic obstructive pulmonary disease (COPD) and other respiratory system diseases.
Skin diseases: eczema, psoriasis, urticaria, etc.
Endocrine diseases: treatment of hypothyroidism, polycystic ovary syndrome, etc.
Tumor treatment: breast cancer, prostate cancer, etc.

Steroid Hormone Synthesis Capabilities

Green and sustainability are the current themes of anabolic steroids, for which the innovation of synthetic technology has started. One of the representative technologies is the use of heterogeneous catalysts, such as Bismuth reagents, Allylic oxidation with bismuth (III) and cobalt (II) salts, Allylic oxidation with dirhodium (II, II) caprolactamate, etc. The use of these catalysts can reduce environmental pollution while promoting the synthesis rate. Microwave-assisted synthesis can expand the scope of the reaction to meet industrial production. Microorganisms can also be used for biotransformation to synthesize steroids, the principle of which is enzymatic catalysis. Microbial reactions are specific and can functionalize groups at specific positions without affecting groups at other positions. To synthesize complex natural compounds such as steroids, strong synthesis capabilities are required. Here are some of our synthesis capabilities:

steroid-hormone-synthesis-capabilities

Hydrogenation Reaction (hundreds of kilograms/batch)
Ultra-low Temperature Reaction (below -80℃)
Chlorination Reaction (hundreds of kilograms/batch)
Ammonia Reaction
Metal Catalyzed Reaction
Bromination Reaction (thousands of kilograms/batch)
Iodination Reaction
Cyanation Reaction (hundreds of kilograms/batch)
Carbonylation Reaction
Fluorination Reaction
Esterification Reaction
Amidation Reaction
Allylation Reaction
Ring Cleavage & Cyclization Reaction, etc.

In short, BOC Sciences is using the concept of green chemistry to actively solve the shortcomings of steroid chemistry, such as difficulty in post-processing, low yield, and weak selectivity. Our integrated development service can provide a one-stop solution for your steroid and hormone products. We will always aim to increase production and minimize side effect, design and develop the steroids and other hormones you need. No matter what your needs are, we are committed to your success.

We are well aware that steroids are important scaffolds for synthetic drug molecules. They have a wide range of biological and pharmacological properties and have broad prospects in the pharmaceutical industry. We are willing to work with you to continue to explore the field of innovative drugs for steroids and other hormones, and solve their urgent needs for more patients. If you are interested in our steroids & hormones custom development service, please contact us immediately. In addition, custom development of macromolecules such as peptides and oligonucleotides are also quickly available at BOC Sciences.

Reference