Antibody-drug Conjugate (ADC) Custom Development
BOC Sciences, as an expert in chemical coupling, focuses on overcoming challenges in ADC development. We have many years of experience in ADC and professional biological coupling development services, equipped with a professional team of chemists, and can provide you with the professional knowledge, equipments and capabilities you need. We provide customized solutions from early detection of bioconjugation to development and clinical manufacturing.
ADC & Bioconjugation
ADC is formed by combining a small molecule drug with biological activity and a monoclonal antibody through a linker. Antibodies are responsible for binding to antigens on the surface of tumor cells. When ADC is phagocytosed by tumor cells, the small molecule drugs contained in it will release and kill tumor cells. ADC can kill target cells more efficiently than pure antibody drugs. However, the design of ADC is also more complicated than that of antibodies, and it is necessary to consider the three components of antibody, linker, and small molecule drugs and a reasonable combination between them. Therefore, BOC Sciences can develop ADCs that suit your needs.
Our ADC development customized services include:
- Proprietary antibody/target screening
- Effective linker design
- Cytotoxin API comprehensive customization
- Conjugation technical support
- Characterization analysis
- Usability analysis
ADC Process Development & Manufacturing
In addition to custom development, BOC Sciences is a leading provider of ADC process development and cGMP manufacturing. Our R&D team is dedicated to optimizing the ADC manufacturing process to increase yield and reduce cost. We have a cGMP manufacturing facility that complies with a global quality assurance and management support system (certified to ISO 9001 and ISO 13485). Additionally, BOC Sciences can isolate and purify ADCs from reaction mixtures using state-of-the-art purification technologies. We use various chromatography methods such as affinity, ion exchange or size exclusion chromatography to remove impurities and obtain high purity ADC products. In addition, BOC Sciences has strong analytical capabilities for characterizing ADC products, such as mass spectrometry, HPLC, ELISA or bioassays. We can perform stability studies to assess ADC shelf life and storage conditions.
ADC Technical Support Platforms
Biological Coupling Technology Platform The core of ADC drug production is to couple antibodies, linkers and small molecule drugs to form a single molecule. Among them, the conjugation between macromolecular antibodies and small molecule linkers is technically more challenging. Our industry-leading bioconjugation technology platform is developed by authoritative experts to support customers' drug development projects. Our bioconjugates include but are not limited to ADCs, antibodies, small molecules, biotin, peptides, amino acids, liposomes, oligonucleotides, polysaccharides, enzymes and nucleic acids.
Impurity Control Platform During ADC synthesis and manufacturing, impurities such as unconjugated antibody, free drug, or linker molecules can affect the homogeneity, stability, and efficacy of ADCs. The impurity removal process is critical to ensure the safety and efficacy of ADCs. We are equipped with a professional impurity removal purification process to ensure the effective removal of impurities while maintaining the integrity of the ADC.
ADC Drug Development Workflow
In summary, BOC Sciences offers a range of custom development services for ADCs, including design, synthesis, conjugation, and characterization. We can work with clients to develop ADCs with specific target binding, drug potency and stability profiles using a variety of linker technologies and drug payloads. We also provide analytical and quality control services to ensure the purity and potency of the final product. , currently, we have experience working with a range of therapeutic targets and drug classes, and can provide customized solutions to meet the unique needs of each project. If you are interested in our custom development services, please contact us immediately.
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