Prostaglandins Custom Development

Prostaglandins custom development

BOC Sciences has leading technologies for the synthesis and production of prostaglandins (PGs). As the world's leading prostaglandin supplier, we focus on the R&D and large-scale production of customized prostaglandins. A team of experts from BOC Sciences provides one-on-one client consultations to understand the client's specific needs for prostaglandin development, including desired chemistry, purity and quantity. In addition to development and manufacturing services, we also provide characterization services for prostaglandin compounds such as HPLC, NMR and mass spectrometry to ensure they meet required specifications.

What are Prostaglandins?

Prostaglandins are a group of lipid compounds that are derived from arachidonic acid, a fatty acid found in cell membranes. Structurally, prostaglandins are composed of a 20-carbon chain that includes a cyclopentane ring and a carboxylic acid group. The different types of prostaglandins are distinguished by the presence of different functional groups on the cyclopentane ring. Pharmaceutically, prostaglandins have a wide range of activities. They can act as vasodilators, promoting blood flow and reducing blood pressure. They can also act as vasoconstrictors, reducing blood flow and increasing blood pressure. Prostaglandins can also modulate inflammation, acting as either pro-inflammatory or anti-inflammatory agents depending on the context. In addition, prostaglandins have been studied for their potential use in cancer therapy, as they have been shown to have anti-tumor effects in some cases. Overall, prostaglandins are a diverse group of compounds with a wide range of pharmaceutical activities and applications.

Our Prostaglandin R&D Capabilities

Prostaglandins are available from BOC Sciences in a variety of natural and synthetic derivatives. Moreover, we offer prostaglandins and associated compounds unique synthesis services, enabling the creation of brand-new analogs with enhanced pharmacological properties. Our prostaglandins have been studied in a number of fields, such as pain control, inflammation, and reproductive health. Our products are of the highest caliber, and we place a high value on client pleasure.

Custom Synthesis of Prostaglandins: BOC Sciences can provide custom synthesis services of prostaglandin compounds, allowing researchers to obtain rare or difficult-to-synthesize prostaglandins for their research. Our team of synthetic chemists have extensive experience in prostaglandin synthesis and are able to deliver high-quality compounds with rapid turnaround times.

Prostaglandin Analysis Services: BOC Sciences offers a range of analytical services to support prostaglandin research, including HPLC, LC-MS and NMR analysis. These services ensure the purity and quality of prostaglandin compounds, allowing researchers to confidently use them in research.

Structure-activity Relationship (SAR) of Prostaglandins: BOC Sciences can perform SAR studies to help researchers understand the relationship between the structure of prostaglandin compounds and their biological activities. These studies may provide valuable insights into the design of new prostaglandin-based therapies.

Pharmacokinetic Study of Prostaglandins: BOC Sciences offers pharmacokinetic studies to evaluate the absorption, distribution, metabolism, and excretion of prostaglandin compounds in the body. These studies are critical in determining the safety and effectiveness of new prostaglandin drugs.

Our Prostaglandin Manufacturing Capabilities

As a contract research organization, BOC Sciences provides custom synthesis and manufacturing services for a variety of chemicals, including prostaglandins, peptides, oligonucleotides and fermented products. With a team of experienced chemists and state-of-the-art facilities, we are able to provide high quality products at competitive prices. BOC Sciences also has state-of-the-art facilities and equipment for the purification and analysis of prostaglandin API. We can supply various types of prostaglandin APIs, including PGF2α, PGE1, PGE2, and PGD2, in varying quantities and levels of purity to meet our customers' specific needs.

cGMP-compliant production: BOC Sciences operates cGMP-compliant production facilities that meet the highest quality standards for the production of prostaglandin compounds. These facilities are equipped with state-of-the-art equipment and adhere to strict quality control procedures to ensure the purity and consistency of prostaglandin products.

Amplification capacity: BOC Sciences can expand the production of prostaglandin compounds from milligrams to kilograms, enabling researchers to obtain the number of compounds required for preclinical and clinical studies. Our manufacturing team has rich experience in process optimization and can provide high-quality prostaglandin compounds of any size.

Customized formulation: BOC Sciences can provide customized formulation services for prostaglandin compounds, including the development of drug delivery systems and dosage forms according to the specific requirements of researchers and pharmaceutical companies. These services enable researchers to optimize the bioavailability and efficacy of prostaglandin-based therapies.

Regulatory support: BOC Sciences provides regulatory support services to help researchers and pharmaceutical companies cope with the complex regulatory environment of prostaglandin drugs. Our regulatory experts can provide guidance on regulatory requirements, assist in documentation and submission, and ensure compliance with relevant regulations.

We use integrated process facilities and the most cutting-edge technology available in the market to offer high-quality products to our clients while reducing the time and expense of project building. Our manufacturing facilities are compliant with ICH, FDA, EMA, and NMPA standards and feature cutting-edge machinery, elite expert teams, and global standard management systems. We strive to enhance production with cutting-edge procedures that adhere to cGMP international standards.

Our Manufacturing Facilities

  • Low temperature reactors
  • Extraction and leaching systems
  • Crystallization equipment
  • Filter dryers
  • Rotary evaporators
  • Preparative high performance liquid chromatography
  • Silica gel columns

Why Choose BOC Sciences?

  • Realize step-by-step monitoring from key intermediates to the synthesis and production of prostaglandin active pharmaceutical ingredients, with a number of independent patented technologies, forming a complete industrial value chain.
  • The production capacity of hundreds of kilograms of APIs, the production plant is equipped with advanced production equipment, assembly lines, instrumentation and control systems.
  • Experienced production management personnel, professional technical workers, and regular training and qualification confirmation systems are the backbone of the lean production of pharmaceuticals.
  • Strict process verification and cleaning verification ensure stable and reliable production process and reduce the possibility of impurity contamination.
  • Real-time environmental monitoring and strict process control are carried out in the production process to ensure that the entire production process meets the established process requirements.
  • Continuous and effective preventive maintenance system and measurement management control escort standardized production.

BOC Sciences boasts a magnificent trinity of flexibility, efficiency, and unwavering stability when it comes to its manufacturing capabilities. This formidable prowess allows us to unleash a vast array of modified prostaglandin APIs upon the world. If you are interested in our custom development services, please contact us immediately.

Case Study

The research and development efforts of a leading pharmaceutical company specializing in drug development for eye diseases required a reliable and efficient source of prostaglandins. They have struggled with impurity issues and are slow to produce using current synthesis methods. After learning that BOC Sciences offered custom development of prostaglandins, they explained their specific requirements and challenges to us. Our experienced team of chemists and researchers then focus on improving efficiency and reducing impurities in the final product by optimizing traditional prostaglandin synthesis routes. Through our innovative methods and expertise in chemical synthesis, we provide our customers with a high-quality batch of prostaglandins in a fraction of the time required using previous methods, and with an extremely high degree of purity.

Case study of prostaglandins custom development


1. What type of compound is prostaglandin?

Prostaglandins are a class of oxygenated arachidonic acid metabolites that include prostaglandin F2α (PGF2α), prostaglandin D2 (PGD2), prostaglandin E2 (PGE2), thromboxane A2 (TXA2), and prostacyclin (PGI2). They exert various biological functions in the human body by directly acting on nine types of lipid G-protein-coupled receptors (GPCRs), including prostaglandin F2α receptor (FP).

2. What is the composition of prostaglandins?

Prostaglandins are relatively simple, consisting of a 20-carbon fatty acid chain derived from arachidonic acid, an omega-6 fatty acid found in cell membranes. Prostaglandins are synthesized in the body through a series of enzymatic reactions that convert arachidonic acid into prostaglandin H2, which is then further metabolized into different types of prostaglandins.

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