Crystallization Technology Platform
Since more than 90% of drugs exist in the form of crystals, crystallization technology is widely used in the field of pharmaceutical production. BOC Sciences has rich experience in drug crystal form research. Our crystallization technology platform uses the most advanced instruments and equipment, and is in charge of a professional team of chemists, providing professional technical services such as crystal type screening and crystallization process development and optimization.
For drug development, even the same drug component, under different crystal structures, will have different physical properties (such as solubility, water absorption, melting point). This directly leads to obvious differences in drug properties such as bioavailability and product stability. Therefore, in order to avoid various problems in the later analysis and testing and hinder the speed of product launch, detailed crystal type screening and investigation must be carried out in the early stage of drug development.
Solid-state screening and characterization
The solid-state form of the drug directly affects the solubility, dissolution rate, melting point, stability, tabletability and other properties of the active pharmaceutical ingredients, and these properties will further affect the efficacy of the drug. Therefore, it is necessary to use various experimental methods to obtain the various solid forms of drugs that may exist, use a variety of solid-state analysis techniques to characterize the physical and chemical properties of various forms, and use multi-disciplinary comprehensive methods to evaluate the performance of superior types of biopharmaceuticals to screen a superior drug crystal form suitable for production, high bioavailability, and favorable for preparations is produced. BOC Sciences can provide polymorph, salt, eutectic screening and amorphous dispersion screening. Our characterization and analysis instruments and equipment include X-ray powder diffractometer, differential scanning calorimeter, Raman microspectrometer, scanning electron microscope, etc., which can fully characterize the crystal form of the products.
Crystallization process development
We provide process development for specific crystal types according to customer needs. Our crystallization technology includes conventional cooling crystallization, fusion crystallization and reaction crystallization, as well as spherical crystallization, ultrasonic crystallization, supercritical fluid crystallization, high-throughput crystallization, quasi-emulsification crystallization, micro-recrystallization, crystal mordant, etc. technology. We will first select the most stable crystal form for customers while ensuring product quality; then we will find the best crystallization process within the safe operating range.
Crystallization process optimization
In the case that the crystallization process goal has been determined, different research methods are selected for different process goals. Our crystallization process optimization is generally carried out from the following six aspects:
In addition to the above services, we also provide customers with pre-clinical prescription development, compound solid state and physical and chemical properties analysis and overall solutions.
If you are interested in our crystallization technology platform, please contact us immediately.