Technology Platforms

With technology as its core driving force, BOC Sciences is committed to providing high-tech development and production platforms. Our R&D center has more than 2,000 scientists and nine world-class technology platforms, which can meet the development and manufacturing of various chemical synthesis drugs. BOC Sciences is strengthening strategic deployment, exploring new business areas, deploying new technology platforms, and continuously improving our CDMO service capabilities.

Drug Development Process

In addition to small molecule compounds in the traditional sense (such as aspirin, artemisinin), the concept of modern drugs also includes peptides, proteins and antibodies, (oligo)nucleotides, small molecule-antibody complexes, and vaccines. In addition, the development of new drugs requires multi-disciplinary collaboration, such as process chemistry, toxicology, pharmacology, pharmacokinetics, formulation, and other disciplines. Additionally, all majors require support in analytical chemistry. Currently, the preclinical drug development process mainly includes:

Formulation development is an important part of drug research and development. Early formulation research does not require complete formula development. All research can focus on toxicology studies and convenient dosing during Phase I clinical trials. The purpose is to push the candidate drug into clinical practice as soon as possible. As the project progresses, research on dosing methods and prescriptions becomes more and more comprehensive. For example, some drugs have poor gastrointestinal absorption and need to be developed into injections. Some drugs lose their activity in gastric acid, so they need to be developed into enteric-coated preparations. Some compounds have poor solubility, and this problem can be partially solved through preparation.

Our Drug Technology Platforms

In the actual experimental process, if you want to ensure the stability and reproducibility of the synthesis experiment, you must comprehensively consider the factors that affect the synthesis experiment and control them accordingly. For example, sequence design, synthesis route design, condition selection, equipment selection, purification method selection, etc. will all affect the quality of the product. Based on this, we have launched a variety of drug development process platforms to help customers provide one-stop services from drug development to clinical practice.

Continuous Flow Chemistry Platform

Continuous flow chemistry platforms simplify chemical reactions by conducting them in a continuous manner, resulting in higher yields, shorter reaction times, and improved safety. Our efficient, flexible and scalable continuous chemistry platform can meet nearly a hundred reaction types and provide comprehensive process development and optimization services, which is very suitable for process optimization and synthesis route amplification.

Biological Catalysis Platform

The high-quality catalytic platform provides services such as new enzyme development, fermentation, immobilization, and catalytic process development to better assist green production. Our biocatalysis platform harnesses the power of enzymes and biocatalysts to promote green and sustainable chemical transformations. By leveraging the specificity and efficiency of biocatalysts, we provide cost-effective and environmentally friendly synthetic routes to complex molecules.

HPAPIs Development Platform

HPAPIs are a class of compounds that exhibit high pharmacological potency at low doses, making them critical for the development of targeted and effective therapies for various diseases. Our HPAPI development platform offers comprehensive services including custom synthesis, process optimization, impurity analysis and analytical characterization of HPAPIs.

Crystallization Technology Platform

We have an experienced team of scientists and engineers who focus on crystallization technology, including crystal form screening, crystallization process development and crystallization process optimization. We can develop and optimize crystallization processes to produce high-quality crystals with desired properties such as particle size, shape and purity. We can also optimize existing crystallization processes to increase efficiency, yield and product quality.

Supercritical Fluid Chromatography Platform

The supercritical fluid chromatography platform is mainly used for the separation and identification of complex raw materials and intermediates, especially the screening of chiral analysis methods; and the development of separation and purification methods during amplification. The platform offers the advantages of rapid analysis, reduced solvent consumption, and compatibility with a wide range of compounds.

Biological Coupling Technology Platform

Bioconjugation technology platforms enable the conjugation of biomolecules for a variety of applications, including drug delivery, diagnostics and therapy. Our platform supports efficient and site-specific attachment of biomolecules, ensuring the desired functionality and stability of the conjugates. Integrated conjugation technology platforms from early-stage R&D to cGMP production can also provide complete analytical methods for the characterization of conjugated drugs.

Impurity Control Platform

The impurity control platform provides comprehensive solutions for the identification, characterization, and removal of impurities in compounds. Control impurities by adding appropriate controls during process development and scale-up. Then by employing advanced analytical techniques and purification methods, we ensure the purity and quality of the final product.

Peptide Synthesis Platform

BOC Sciences' peptide synthesis platform is committed to providing fast turnaround times and competitive pricing, making it a cost-effective solution for your peptide synthesis needs. The platform also adheres to the highest quality control and assurance standards and has rigorous testing protocols in place to verify the identity, purity and stability of synthetic peptides.

Asymmetric Hydrogenation Platform

BOC Sciences' asymmetric hydrogenation platform may provide a range of catalysts, ligands and expertise to efficiently and selectively produce chiral compounds via hydrogenation reactions. These catalysts and ligands can be tailored to specific substrates or target molecules, allowing reactions to be tailored to meet the needs of customers in various industries.

High-throughput Synthesis Platform

The world's leading custom platform for high-throughput synthesis of oligonucleotides, capable of providing synthesis scales from micrograms to kilograms. This high-throughput capability significantly increases the speed of oligonucleotide synthesis, allowing the production of large quantities of oligonucleotides in a fraction of the time compared to traditional methods. This is particularly beneficial for projects requiring large quantities of oligonucleotides, such as large-scale genomics studies or high-throughput screening assays.

Case Study

Isomer Screening and Research on Multiple Chiral Centers

A pharmaceutical company approached BOC Sciences with a challenging research project involving the synthesis and characterization of small molecule isomers of a new drug candidate. The company is interested in exploring potential differences in biological activity between the various isomers of the molecule, with the goal of identifying the most potent and selective isomers for further development.

Our team of expert chemists at the Chiral Center immediately began synthesizing different isomers of small molecules using a combination of traditional organic synthesis techniques and cutting-edge chiral separation methods. By carefully controlling the stereochemistry of the molecules during synthesis, we were able to generate pure samples of each isomer for further analysis. Next, our team conducted a series of in vitro and in vivo studies to evaluate the biological activity of each isomer. Based on our findings, we recommend the most promising isomers for further preclinical development, providing valuable insights to pharmaceutical companies.

FAQ

1. What is continuous flow chemistry?

Continuous flow chemistry is a method of conducting chemical reactions in a continuous manner, as opposed to traditional batch processes where reactions occur in discrete steps. In continuous flow chemistry, reagents are continuously pumped into the reactor, where the reaction occurs, and then continuously removed from the system. This allows precise control of reaction conditions such as temperature, pressure and residence time, resulting in more efficient and consistent reactions.

2. What are the three methods of crystallization?

Crystallization is the process by which a solid forms from a solution, melt, or vapor and adopts a highly ordered three-dimensional structure called a crystal lattice. There are three main methods of crystallization commonly used in chemistry and materials science: evaporation, cooling and precipitation. Evaporation is often used for the crystallization of salts, such as sodium chloride (table salt). Cooling is another common crystallization method, especially for substances that are soluble in hot solvents but poorly soluble in cold solvents. Precipitation involves the addition of a precipitating agent to a solution containing the solute to be crystallized. The precipitating agent reacts with the solute to form an insoluble compound, which then precipitates out of solution as solid crystals.

3. What is supercritical fluid chromatography?

Supercritical fluid chromatography (SFC) is a powerful analytical technique used to separate and analyze a wide range of compounds in a variety of industries, including pharmaceuticals, food and beverages, environmental and forensic science. SFC combines the principles of gas chromatography (GC) and liquid chromatography (LC) to provide a unique and versatile method for the separation and analysis of complex mixtures of compounds.

4. What is supercritical fluid chromatography used for?

Supercritical fluid chromatography (SFC) is commonly used in the pharmaceutical industry for the analysis of drug compounds, impurities, and metabolites. Its ability to separate a wide range of compounds with high efficiency and resolution makes it an ideal technology for quality control, method development, and research and development in drug discovery. SFC is also used for the analysis of flavors, flavors and additives in the food and beverage industry, and for the analysis of contaminants, toxins and illegal substances in environmental and forensic science.