Angiotensin Receptor Blockers (Sartans) Custom Development
BOC Sciences can help you develop angiotensin receptor blockers (Sartans) type of special antihypertensive API. Hypertension is a chronic disease that requires patients to take long-term medication to control it; its global prevalence is increasing year by year, resulting in the continuous expansion of the demand for antihypertensive drugs. BOC Sciences can provide imitation services for some original research products whose patents are about to expire, and can also cooperate with you to develop innovative original research drugs with patented technology. Our strong development capabilities help you quickly expand the global antihypertensive drug market and become an industry leader.
The structure of sartan drugs is mainly non-peptide, which can be divided into three types based on the structural characteristics of drugs. First, biphenyl tetrazolium, which contains calcium in the structure of these drugs, is the basic structure of biphenyl tetrazolium. Second, non-biphenyltetrazolium drugs, which contain heterocyclic structural features. Third, non-heterocyclic drugs. This type of drugs has many structures and does not have a heterocyclic structure. Although the three structures are different, they have similar pharmacological effects. 
Fig.1 Chemical structures and names of sartans.
Sartan drugs can specifically block angiotensin II at the receptor level, dilate blood vessels, lower blood pressure, and achieve the purpose of treatment. Sartan drugs can be used alone or in combination with other drugs. The common combination method is combined diuretics and dipine antihypertensive drugs. Different antihypertensive mechanisms can contain each other and offset the occurrence of side effects.
We use superb chemical synthesis technology to design the synthetic route of new types of sartan compounds, through the combination of nucleophilic, addition, Staudinger, alkylation, azide, acylation, transesterification, Curtius rearrangement, condensation, nitration, etc. rich response types. In addition, we can also modify existing sartan compounds through structural addition and derivatization.
The synthesis of sartan compounds mostly requires more reaction steps, and the complexity of the process leads to the diversity of impurities. Research on impurities is helpful to optimize the synthesis process and quality control. We can use electron bombardment mass spectrometry and electrospray cascade mass spectrometry to split the target impurities by secondary mass spectrometry, and identify the impurity structure by comparing the mass spectrometry fragmentation law of sartan drugs.
We can use analytical methods to determine the quality of the drug in the manufacturing stage and its measurement in the human body. Our methods include spectrophotometric (UV, Vis) analysis, derivative ultraviolet spectroscopy, high performance liquid chromatography (HPLC), high performance thin layer chromatography (HPTLC), capillary zone electrophoresis (CZE), micellar electrokinetic capillary chromatography (MEKC) and voltammetry etc.
Our stability research includes long-term accelerated testing and stress testing, which can specifically include studies on hydrolysis, photolysis, and oxidation.
If you are interested in our angiotensin receptor blockers (Sartans) custom development service, please contact us immediately.
- Ma Haili. Pharmacological effects and clinical application analysis of sartan drugs[J]. Medical Diet and Health, 2021.
- Muszalska I, et al. Analysis of Sartans: A Review[J]. Journal of Pharmaceutical Sciences, 2014.