Contrast Media Custom Development

Contrast Media Custom Development

Contrast Media Custom Development

BOC Sciences can provide you with the development services of new contrast media, help you master your own technology, and seize the leading position in the future contrast media market. With the popularization of CT and MRI equipment, the demand for contrast media continues to increase, and the market expands significantly. In addition, the current mainstream iodine contrast media and magnetic contrast media on the market have certain safety problems, which also prompts the development of safer new contrast media. We have rich experience in contrast media development, give full play to the team's synthetic technology advantages and pharmaceutical process experience, and are good at the whole industry chain development of key intermediates, APIs and preparations. Our goal is to research and develop innovative contrast media that better meet your needs.


The purpose of the contrast media is to absorb X-rays, thereby distinguishing the organ to be diagnosed from the surrounding tissue. The classification of contrast media is based on market share, and the top three are X-CT contrast media, MRI contrast media and ultrasound contrast media. Among them, X-CT contrast media account for more than 50%, and can be subdivided into barium sulfate and iodine contrast media. Iodine-based contrast media are one of the most widely used drugs for intravascular administration, and are mainly divided into ionic and non-ionic types. Currently, iodine-based contrast media in clinical use are all non-ionic. Their basic structure is 3-acetyl-2,4,6-tribenzoic acid, which is a benzene ring containing 3 iodine, with long side chains, rich in hydroxyl groups, and uniformly distributed around the benzene core. Two of these side chains are usually the same, giving the compound a bivalent structure. [1]

Although contrast media is considered a relatively safe drug, adverse effects can occur. Side effects of iodinated contrast media include allergic-type reactions and kidney damage, while magnetic contrast media may cause nephrogenic systemic fibrosis.

Our Services

Synthetic Development

Our chemists are able to combine the extensive literature to devise multiple synthetic routes using a variety of reaction types such as substitution, amidation, acetylation, hydrolysis, alkylation, and more.

Process Optimization

Taking the purity and yield of the product as the standard, the experimental conditions were optimized to determine the best process.


Analytical studies were carried out using NMR, MS, FT-IR, GPC, etc.

If you are interested in our contrast media custom development service, please contact us immediately.

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BOC Sciences