Tyrosine Kinase Inhibitors (Tinibs) Custom Development

BOC Sciences can provide synthesis and development services for tinib drugs. Trinis are a new class of biologically targeted cancer drugs. With the increase in the number of tumor patients, the global demand for anti-tumor drugs is increasing year by year. And tinib drugs have become a hot spot in the field of anti-tumor in recent years, and their market prospects for both generic drug development and new drug research and development are widely optimistic. BOC Sciences is a CDMO service provider with R&D and production capabilities for independently developing anti-cancer drugs, and can reach a good cooperative relationship with you.

Introduction

Trinis are a class of antitumor drugs that target protein tyrosine kinases, so they are also called tyrosine kinase inhibitors. Its mechanism of action is to react with the adenosine triphosphate binding site, thereby interfering with the actual binding between tyrosine kinase and adenosine triphosphate, inhibiting the actual activity of tyrosine kinase, and finally inhibiting the autophosphorylation of tyrosine, blocking the down-transmission pathway of epidermal growth factor receptor signaling, and eventually kills the tumor cells.

Development Process

Our Services

Our services include but are not limited to the following:

Synthetic Design

We use the existing tinib drugs as lead compounds, carry out structural transformation and structural modification, introduce active pharmacophore, and carry out structural modification on the active pharmacophore, design and synthesize a variety of new derivatives, and then use anti-tumor activity was used as an indicator for screening.

Crafts Improvement

Through the analysis of the synthesis method of tinib, we control the ratio of raw materials, reaction temperature, time and other aspects in the synthesis of tinib to achieve the optimization and improvement of the process, and at the same time control the generation of reaction by-products in the synthesis of different steps, and then optimize the synthesis of tinib craft.

Solid State Studies

We use high performance liquid chromatography, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and infrared spectroscopy to study the solid form of tinib. We can also combine the crystallization thermodynamics and desolvation mechanism to systematically optimize the drug crystallization process.

If you are interested in our tyrosine kinase inhibitors (Tinibs) custom development service, please contact us immediately.

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